Tipton is a city in Moniteau County, Missouri, United States. The population was 2,920 as of the 2020 census, down from 3,262 in 2010. It is part of the Jefferson City metropolitan area. Tipton was a predominantly German-American community, in the region known as the Missouri Weinstrasse. Tipton was an eastern terminus of the Butterfield Overland Mail when it was launched in 1858. The route was connected to St. Louis by the Pacific Railroad. Tipton is named for William Tipton Seely, a businessman in nearby Round Hill. He received the land for his service in the War of 1812. From Tipton, a stage went to Fort Smith, Arkansas. From there, it went on to Los Angeles and San Francisco via a route through southern Arizona and New Mexico. The first run went from Tipton to San Francisco from September 16 to October 10, 1858. The route antedated the Pony Express by two years. The route was designated a national historic trail in 2023.
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