Almost 35% of drugs approved by the Food and Drug Administration work by targeting G protein-coupled receptors (GPCRs), proteins embedded in cell membranes that allow cells to communicate with ...

Our News & Views discussed a recent paper 6 that clearly stated that the existence of a putative membrane ... receptor couples to a common intracellular signaling pathway in four different cells ...

For example, membrane receptors bind and respond to specific molecules outside the cell, such as hormones, neurotransmitters, the extracellular matrix, and attachment molecules on other cells.

In the cell membrane, TRPM8 acts as a receptor for cold, enabling humans to sense cold. Researchers at ...

Proteins are life's engines, powering processes like muscle movement, vision, and chemical reactions. Their environments-water, lipid membranes, or other condensed phases-are critical to their ...

EPFL researchers have developed a computational method to explicitly consider the impact of water while designing membrane receptors with enhanced stability and signaling, paving the way for novel ...

Proteins are life's engines, powering processes like muscle movement, vision, and chemical reactions. Their ...

Glycoproteins typically bind to receptors on the membrane of a host cell. Viruses that do not bud from the host cell membrane do not have an envelope, so they are called “naked” or ...

A recent study has uncovered key insights into the differing tumour rejection behaviours of chimeric antigen receptor T cells ...

Adhesion G protein-coupled receptors (GPCRs) are a group of cell-surface sensors associated with many body functions and diseases. However, they are not yet sufficiently understood to be exploited for ...

When bound to the receptor, toxins can act at the cell membrane by interfering with signal transduction pathways, pore formation or enzymatic activities on membrane compounds. Various enterotoxins ...