Selecting a therapeutic antibody that will become commercially successful is often a huge gamble, with candidates potentially failing at any stage of development. Those that are rushed through the ...

YUMAB uses libraries of close to germline origin ... The resulting antibodies are maximally de-risked with respect to immunogenicity, because every V region sequence has been expressed in a ...

Figure 1: Recombination of V,D, and J Germline Genes into a Functional Antibody (Market and F. Nina Papavasiliou, PLos Biology 1:24-27 Figure 2. Map of the 1Mb human Immunoglobulin heavy chain locus ...

Germline targeting is an immune system-stimulating ... specific responses from the 10E8 B cell precursors and induced antibodies that showed signs of maturing into bNAbs that could reach the ...