SNALP is constructed by three basic lipids: an ionizable cationic lipid (1,2 ... protect the nucleic acid core against degradation by nucleases, sterically stabilize the particles against ...

The method in this study matched up mRNA with just one unique lipid nanoparticle—ionizable amphiphilic Janus dendrimers (IAJDs) which were derived from natural materials and discovered by Virgil ...

The method in this study matched up mRNA with just one unique lipid nanoparticle-ionizable amphiphilic Janus dendrimers (IAJDs) which were derived from natural materials and discovered by Virgil ...

Specifically, I: (i) implemented a lipid-polymer nanoparticle platform for siRNA delivery to bone marrow endothelial cells in vivo to halt myeloma progression, (ii) developed the first-of-its-kind ...

However, LNPs consisting of helper lipids, PEGylated lipids and ionizable lipids can be susceptible to N-oxide-based impurities that can cause the loss of function of the genetic payload. To ensure ...