Ionizable lipid nanoparticles (LNPs) that deliver nucleic acid therapeutics to the liver have been successful in the clinic, but achieving LNP delivery to other organs has been challenging.
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Novel Approach to Lipid Nanoparticle EngineeringTo enhance mRNA distribution, Penn engineers have created an ideal “recipe” for ionizable lipids, essential lipid nanoparticles (LNPs) components, the molecules that underlie COVID-19 vaccines ...
However, LNPs consisting of helper lipids, PEGylated lipids and ionizable lipids can be susceptible to N-oxide-based impurities that can cause the loss of function of the genetic payload. To ensure ...
Nanomedicine. 2014;9(1):105-120. SNALP & its Application. SNALP is constructed by three basic lipids: an ionizable cationic lipid (1,2-dilinoleyloxy-3-dimethylaminopropane), a neutral helper lipid ...
Specifically, I: (i) implemented a lipid-polymer nanoparticle platform for siRNA delivery to bone marrow endothelial cells in vivo to halt myeloma progression, (ii) developed the first-of-its-kind ...
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