More information: Xuexiang Han et al, Optimization of the activity and biodegradability of ionizable lipids for mRNA delivery via directed chemical evolution, Nature Biomedical Engineering (2024 ...

Optimizing the design and delivery of LNPs can greatly enhance their ability to deliver mRNA successfully ... these improved lipids was the difficulty of creating branched ionizable lipids ...

Through a series of structural and functional analyses, they identified a lead formulation, termed MK16 BLNP, that exhibited significantly higher mRNA delivery efficiency than existing lipid ...

Getting mRNA into the brain could allow scientists to instruct brain cells to produce therapeutic proteins that can help ...

More information: Jaclynn A. Meshanni et al, Targeted delivery of TGF-β mRNA to murine lung parenchyma using one-component ionizable amphiphilic Janus Dendrimers, Nature Communications (2025 ...

The global lipid nanoparticles market is expected to grow from USD 271.8 million in 2024 to USD 350.5 million by 2029, with a CAGR of 5.2%, while the LNP services market is projec ...

After various structural and functional analyses, they identified a lead formulation called MK16 BLNP that displayed significantly higher mRNA delivery efficiency than existing FDA-approved lipid ...

SNALP is constructed by three basic lipids: an ionizable cationic lipid (1,2 ... transport and the endosomal escape of siRNA by SNALP delivery had been investigated. It has been shown that SNALPs ...

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I am an interdisciplinary investigator at the interface of biomaterials, immunology, and cancer biology. Trained as a mechanical engineer, I found a passion to apply physical forces to interrogate how ...