P enn Engineers have cooked up a new way to improve mRNA delivery, developing an optimal "recipe" for ionizable lipids—key ingredients in lipid nanoparticles (LNPs), the molecules behind the ...

The structure of CL4F 8-6, the branched ionizable lipid that was most effective in increasing storage stability and LNP-RNA delivery (Image: Yusuke Sato).

Nanomedicine. 2014;9(1):105-120. SNALP & its Application. SNALP is constructed by three basic lipids: an ionizable cationic lipid (1,2-dilinoleyloxy-3-dimethylaminopropane), a neutral helper lipid ...

More information: Namit Chaudhary et al, Amine headgroups in ionizable lipids drive immune responses to lipid nanoparticles ...

The method in this study matched up mRNA with just one unique lipid nanoparticle—ionizable amphiphilic Janus dendrimers (IAJDs) which were derived from natural materials and discovered by Virgil ...

However, LNPs consisting of helper lipids, PEGylated lipids and ionizable lipids can be susceptible to N-oxide-based impurities that can cause the loss of function of the genetic payload. To ensure ...