The LNP-mRNA modality is a novel approach that uses lipid nanoparticles to deliver messenger RNA into cells. The mRNA acts as ...

Lipid nanoparticles (LNPs) are primed to revolutionize the development ... lipids, proteins, antibodies, and assay kits to support research in a variety of topics. Cayman also offers several custom ...

Genetic medicines could treat certain diseases, however, the current delivery systems available—viral vectors and lipid nanoparticles (LNPs)—pose unique challenges for gene therapy applications. For ...

Roche announced its next generation assay received FDA 510(k) clearance for the measurement of lipoprotein(a) for assessment ...

Lipid nanoparticles (LNPs ... Peer’s group is still testing the thermostable lipids they developed, but he hopes they can make mRNA vaccines available to more countries, especially in the ...

We used lipid nanoparticles to deliver mRNA and siRNA to human PCa cells to evaluate our technique’s ability to both restore the lost PTEN and silence the overexpressed AR. Our strategy could ...

Ionizable lipid nanoparticles (LNPs ... Cell culture LNP delivery assays are poor predictors of in vivo fate, so an in vivo screening approach was used. The authors designed a library of 98 ...

A new framework bridges a gap in understanding RNA therapeutics by linking the structure of lipid nanoparticles to immune ...

Function-engineerable nanoparticles in combination with the advantageous effects of various functional lipid components enable achievement of enhanced blood stability, decreased toxicity and ...

We used lipid nanoparticles to deliver mRNA and siRNA to human PCa cells to evaluate our technique's ability to both restore the lost PTEN and silence the overexpressed AR. Our strategy could also ...

Equipped with an effective delivery system, Siegwart and his team set out to test the system ... immunoblotting and chemical assays, which revealed restoration of CFTR levels and function. “The goal ...

The recent success of the mRNA-LNP vaccines fueled biopharma to explore lipid-based nanoparticles for advanced drug delivery. The industry is now poised to exploit the full therapeutic potential ...