Charged nanoparticles can alter the local physical properties of lipid membranes, which could shed new light on the interactions between living cells and nanomaterials. An emerging 'rule of thumb ...

From vaccines to personalized cancer therapies, scientists are studying the use of mRNA across many clinical applications. However, there are several factors that are unique to mRNA drug product ...

Lipid nanoparticles (LNPs) transport small molecules into the body. The most well-known LNP cargo is mRNA, the key constituent of some of the early vaccines against COVID-19. But that is just one ...

Penn Engineers have cooked up a new way to improve mRNA delivery, developing an optimal "recipe" for ionizable lipids—key ingredients in lipid nanoparticles (LNPs), the molecules behind the ...

A new framework bridges a gap in understanding RNA therapeutics by linking the structure of lipid nanoparticles to immune ...