But it was mRNA where LNPs proved most effective, primarily because LNPs are comprised of positively charged lipid nanoparticles that encapsulate negatively charged mRNA. Once in the body ...

Lipids are made from long chains of fatty ... because the negatively charged silica was attracted to the positively charged thioester. On the silica surface, the cysteine and thioesters ...

We describe a novel method allowing the efficient encapsulation of cisplatin in a lipid formulation ... of cisplatin in the presence of negatively charged phospholipids. The method is unique ...