Antibodies are a major component of adaptive immunity against ... of which the D-segment is short and hypervariable to a point that germline sequences do not provide a functional template for sequence ...

Background: Although immunoglobulin (Ig) alleles play a pivotal role in the antibody response to pathogens, research to understand their role in the humoral immune response is still limited. Methods: ...

The genetic locus encoding Ig is critical for vertebrate humoral immune responses and diverse antibody repertoires ... Using Geneious Prime (Version: 2023.2.1), we aligned the germline C gene ...

This feature also distinguished ACPA-IgG from antibodies against recall antigens ... requires glycosylation consensus sites in the protein sequence and as these are lacking in the ...

It has been estimated that the human immune system can produce up to 1 quintillion different antibodies by changing the sequence of these amino acids, helping to ensure that the body can respond ...

Antibodies, which are crucial for therapeutic and immune functions, owe their specificity to the hypervariable regions within them. These regions display remarkable sequence variability ...

Bispecific antibodies (bispecifics) can simultaneously target two distinct antigens or epitopes, offering novel therapeutic strategies such as enhancing immune cell targeting of cancer cells or ...

Induces potent and long-lasting immune responses to defined antigens or whole pathogens (particles), mainly through the ...

Antibodies that bind to a previously untargeted portion of the malaria parasite could lead to new monoclonal antibody treatments and vaccines for malaria. A novel class of antibodies that binds to ...

During a Case-Based Roundtable event, Laura Huppert, MD, reviewed antibody-drug conjugates for a patient with metastatic ...