The strong shear stress altered the membrane lipid microdomain structure of endocardial cells, which activated mTORC2 and PKC and promoted Notch1 cleavage even in the absence of strong ligand ...

Try as I might, entertaining is usually a hustle for me. No matter how much I plan, the final 30 minutes before a dinner party is pure mayhem. I’m usually barefoot, covered in flour, still in ...

Stress can be acute or chronic and can lead to fatigue, headaches, upset stomach, nervousness, and irritability or anger. Exercising regularly, getting enough sleep, and eating a nutritious diet ...

Rheology is the study of the flow and deformation of materials under applied forces, covering both liquids and solids. It examines how materials respond to stress, strain or flow, revealing ...

This study leveraged scRNA-seq analysis to investigate phenotypic differences by cell-specific gene expression between male and female HAECs under clinically relevant mechanical environments ...

In four aneurysms, the rupture point was near the vortex with low wall shear stress (WSS) and high oscillatory shear index (OSI). In one case, the rupture point was in the flow jet with high WSS. In ...

Figure. MST1-Cx43 axis in disturbed flow (d-flow) mediated endothelial cell-cell communication and vascular dysfunction. Key findings show that disturbed flow (d-flow) inhibits MST1 kinase that allows ...

These findings are consistent with a number of experimental observations and embed firing rate together with oscillatory changes within a switch interpretation of the microcircuit. The microcircuit ...