Briefly, prolactin mainly regulates STAT5 activation through JAK2 ... Novel components of the JAK2-STAT5 signaling pathway. CPAP, centrosomal P4.1-associated protein; CypA, cyclophilin A; CUZD1, zona ...

Pathway analysis indicated that these differentially expressed genes were commonly associated with steroid biosynthesis and metabolism-related signaling ... estrogen (E2), prolactin (PRL), and ...

Signal transducer and activator of transcription (STAT)5A and -5B are latent transcription factors expressed in pancreatic β-cells and other tissues. Prolactin and growth hormone binding to their ...

A new study shows how an anticancer drug triggers an 'outside in' signal that gets it sucked into a cancer cell. The work reveals a new signaling mechanism that could be exploited for delivering other ...

At the −60, +10, +80, and +140 timepoints, blood was sampled from the i.v. line opposite to the one used for administering study drug, for prolactin and cortisol to provide a behaviorally ...

A new study shows how an anticancer drug triggers an "outside in" signal that gets it sucked into a cancer cell. The work, published Jan. 29 in Nature Communications, reveals a new signaling mechanism ...

Northwestern Medicine scientists have uncovered a key pathway controlling tumor growth in B-cell lymphomas, according to a ...

Scientists have uncovered a crucial pathway that links brain cell activity to the activation of genes responsible for ...

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The National Academies of Sciences, Engineering, and Medicine are private, nonprofit institutions that provide expert advice on some of the most pressing challenges facing the nation and world. Our ...

[32] These data indicate that abnormal hormone receptor signaling can contribute to dysfunctional responses to feedback inhibition; however, apart from one subtype of GH-secreting adenomas ...