C&EN16d
Amplification-Free Quantification of Endogenous Mitochondrial DNA Copy Number Using Solid-State Nanopores
Mitochondrial DNA (mtDNA) quantification is crucial in understanding mitochondrial dysfunction, which is linked to a variety of diseases, including cancer and neurodegenerative disorders. Traditional ...
Frontiers25d
Insertion of LINE-1 Retrotransposon Inducing Exon Inversion Causes a Rotor Syndrome Phenotype
Rotor syndrome is a benign condition that presents with conjugated hyperbilirubinemia (Jirsa et al., 1993) and is inherited in an autosomal-recessive manner. The prevalence of Rotor syndrome is ...
Frontiers3y
Genome-Wide Association Study of Root Mealiness and Other Texture-Associated Traits in Cassava
An association mapping panel of 150 cassava accessions sourced from the National Root Crops Research Institute (NRCRI) in Umudike, Nigeria, was used in this study (Supplementary Table S1). These ...
eLife8y
Concerted regulation of ISWI by an autoinhibitory domain and the H4 N-terminal tail
ISWI-family nucleosome remodeling enzymes need the histone H4 N-terminal tail to mobilize nucleosomes. Here we mapped the H4-tail binding pocket of ISWI. Surprisingly the binding site was adjacent to ...
eLife10y
APOBEC3A deaminates transiently exposed single-strand DNA during LINE-1 retrotransposition
Long INterspersed Element-1 (LINE-1 or L1) retrotransposition poses a mutagenic threat to human genomes. Human cells have therefore evolved strategies to regulate L1 retrotransposition. The APOBEC3 ...