Mammalian genomes are organized by multi-level folding, yet how this organization contributes to cell type-specific transcription remain unclear. We uncovered that the nuclear protein SATB1 ...

Degradative fragments of cartilage oligomeric matrix ... preventing COMP degradation by these enzymes. This Review summarizes the evidence demonstrating that ADAMTS-7 and ADAMTS-12 are newly ...

The study, which was a collaboration with Karolinska Institutet and Stockholm University, focused on the enzyme OGG1 ... researchers used what is known as fragment-based drug design instead.

This approach may have limited efficacy due to poor enzyme-to-substrate exposure in the stomach. Moreover, endopeptidases digest proteins into shorter fragments but do not systematically cleave ...