The most recent edition in 2005 highlights again the original contribution in demonstrating that demyelinated plaques may be present in all areas of the grey matter. Modern MRI techniques are ...

The case in the CNS is illustrated. Following demyelination, a demyelinated axon has two possible fates. The normal response to demyelination, at least in most experimental models, is spontaneous ...

He described, in 1906, shadow plaques (“markschattenregeneration”), which are now regarded as a pathognomonic neuropathology feature of demyelinated lesions in multiple sclerosis. From this first ...