This technique is particularly useful for preparing polymeric nanoparticles, but it can also be applied to other materials such as lipids and inorganic compounds. Diagram illustrating the ...
A breakthrough in safely delivering therapeutic DNA to cells could transform treatment for millions suffering from common ...
Charged nanoparticles can alter the local physical properties of lipid membranes, which could shed new light on the interactions between living cells and nanomaterials. An emerging 'rule of thumb ...
Lipid nanoparticles (LNPs) play a critical role for mRNA therapies because they protect the nucleic acid material from degradation as it is delivered to the targeted cell. Precise characterization ...
DNA delivery using lipid nanoparticles results in severe toxicity in mice. However, we find that the incorporation of endogenous anti-inflammatory lipids into the lipid nanoparticles mitigates ...
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Engineers refine lipid nanoparticles for better mRNA therapiesdeveloping an optimal "recipe" for ionizable lipids—key ingredients in lipid nanoparticles (LNPs), the molecules behind the COVID-19 vaccines and other innovative therapies. The method ...
Function-engineerable nanoparticles in combination with the advantageous effects of various functional lipid components enable achievement of enhanced blood stability, decreased toxicity and ...
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mRNA-based drugs successfully delivered to intestine—without passing through the liverMore information: Riccardo Rampado et al, Lipid Nanoparticles With Fine‐Tuned Composition Show Enhanced Colon Targeting as a Platform for mRNA Therapeutics, Advanced Science (2024). DOI: 10.1002 ...
Lipid nanoparticles (LNPs) are primed to revolutionize the development of nucleic acid therapies. The trusted lipid experts at Cayman Chemical provide industry-leading solutions for every stage of LNP ...
Scientists unlock the potential of fenugreek-based lipid nanoparticles to improve diabetes treatment, offering a promising alternative for enhanced drug delivery and long-term stability.
A combination of mRNA and a new lipid nanoparticle could help heal damaged lungs, according to new research from the Perelman School of Medicine at the University of Pennsylvania. Viruses ...
The recent success of the mRNA-LNP vaccines fueled biopharma to explore lipid-based nanoparticles for advanced drug delivery. The industry is now poised to exploit the full therapeutic potential ...
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