Low-fat foods seem like a healthy choice, but hidden additives and sugar could disrupt digestion, gut health, and overall ...

Their findings revealed that these genes play a role in male fertility and in generating small RNA molecules in mature sperm known as tRNA fragments ... to identify the enzymes responsible ...

The researchers ligated immunoprecipitated DNA fragments to a barcoded linker with a type II restriction enzyme that created the PETs; they then subjected these chromatin interaction (ChIA ...

Their findings revealed that these genes play a role in male fertility and in generating small RNA molecules in mature sperm known as tRNA fragments (tRFs ... this study's team aimed to identify the ...

Mammalian genomes are organized by multi-level folding, yet how this organization contributes to cell type-specific transcription remain unclear. We uncovered that the nuclear protein SATB1 ...

"This strategy looks for small molecular fragments that can interact with the enzyme and then uses the best ones as building blocks to create effective drug candidates." The research team tested ...

The study, which was a collaboration with Karolinska Institutet and Stockholm University, focused on the enzyme OGG1 ... researchers used what is known as fragment-based drug design instead.

This strategy looks for small molecular fragments that can interact with the enzyme and then uses the best ones as building blocks to create effective drug candidates." Lutz Tautz, PhD ...

This approach may have limited efficacy due to poor enzyme-to-substrate exposure in the stomach. Moreover, endopeptidases digest proteins into shorter fragments but do not systematically cleave ...

Structure of the protein OGG1 (colour: purple, left) and one of the molecules that inhibit the activity of the enzyme (colour ... used what is known as fragment-based drug design instead.